Important factors in the development of kidney transplantation.
Organ regeneration can not only solve the problem of organ shortage, but also has the advantage of no immune rejection compared with allogeneic organ transplantation, so it has been widely concerned by medical workers and researchers. The difficulty of organ regeneration research is that it is difficult to precisely control the proliferation and differentiation of cells to obtain organ tissues with complete function and physiological structure, which has also become a bottleneck problem in organ regeneration research.
Recently, Australian researchers reported in the top journal Nature their breakthrough in using induced pluripotent stem cells (IPS) to grow kidney tissue. iPS are induced adult stem cells derived from differentiated cells. The researchers used IPS to generate kidney organoids based on an in-depth study of kidney formation mechanisms. These organoids, which contain nephrons, interstitial tissue, and blood vessels, can mimic kidney function in vitro and approach true organ regeneration. This research shows a bright future of induced pluripotent stem cells in the field of organ regeneration, and brings a new dawn for patients with end-stage renal disease.
（Nature： Kidneyorganoids from human iPS cells contain multiple lineages and model humannephrogenesis.）
